| Bioactivity | PROTAC ERα Degrader-10 (Compound 160a) is an orally active degrader for ERα with DC50 of 0.37-1.1 nM, in cells MCF7, T47D and CAMA-1. PROTAC ERα Degrader-10 exhibits antitumor efficacy in mouse model[1]. (Pink: ligand for target protein (HY-170339); Black: linker (HY-30105); Blue: ligand for E3 ligase Cereblon (HY-168055)) |
| CAS | 2421260-43-5 |
| Formula | C45H49N5O4 |
| Molar Mass | 723.90 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fan J, et al., Novel compounds having estrogen receptor alpha degradation activity and uses thereof. US20200157078. |
PROTAC ERα Degrader-10
CAS: 2421260-43-5 F: C45H49N5O4 W: 723.90
PROTAC ERα Degrader-10 (Compound 160a) is an orally active degrader for ERα with DC50 of 0.37-1.1 nM, in cells MCF7, T
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