| Bioactivity | PROTAC ER Degrader-14 (compound 86) is a PTORAC-type Estrogen Receptor/ERR degrader, which is composed of E3 ubiquitin ligase ligand (blue part) (S)-Deoxy-thalidomide (HY-168055), PROTAC Linker (black part) N-Boc-piperazine (HY-30105) and target protein ligand (red part) ER ligand-6 (HY-170341). Among them, E3 ligase + Linker constitute tert-Butyl (S)-4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazine-1-carboxylate (HY-W998234)[1]. |
| CAS | 2504911-73-1 |
| Formula | C44H46FN5O5 |
| Molar Mass | 743.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Preparation of chroman derivatives having estrogen receptor degradation activity and uses thereof. United States, US10800770 B1 2020-10-13. |
PROTAC ER Degrader-14
CAS: 2504911-73-1 F: C44H46FN5O5 W: 743.86
PROTAC ER Degrader-14 (compound 86) is a PTORAC-type Estrogen Receptor/ERR degrader, which is composed of E3 ubiquitin l
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