| Bioactivity | PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 <100 nM. PROTAC EGFR degrader 11 binds CRBN-DDB1 with a Ki of 36 nM. PROTAC EGFR degrader 11 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <100 nM. |
| CAS | 3034244-71-5 |
| Formula | C49H64ClFN10O7S |
| Molar Mass | 991.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Han W, et al., Compound for targeted protein degradation, and use thereof. WO2024072178A1 |
PROTAC EGFR degrader 11
CAS: 3034244-71-5 F: C49H64ClFN10O7S W: 991.61
PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50
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This product is for research use only, not for human use. We do not sell to patients.