| Bioactivity | PROTAC EGFR degrader 10 (Compound B56) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 <100 nM. PROTAC EGFR degrader 10 binds CRBN-DDB1 with a Ki of 37 nM. PROTAC EGFR degrader 10 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <150 nM[1]. |
| CAS | 3034244-56-6 |
| Formula | C49H65ClN10O7S |
| Molar Mass | 973.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Han W, et al., Compound for targeted protein degradation, and use thereof. WO2024072178A1 |
PROTAC EGFR degrader 10
CAS: 3034244-56-6 F: C49H65ClN10O7S W: 973.62
PROTAC EGFR degrader 10 (Compound B56) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50
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