| Bioactivity | PROTAC CRBN ligand-2 (12) is a Biguanide-PROTAC derivative, with an EC50 of 0.15 mM in KP4 cells. PROTAC CRBN ligand-2 (12) demonstrates the ability to alter levels of mitochondrial proteins, notably complexes I and IV[1]. |
| Formula | C33H30N8O8 |
| Molar Mass | 666.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Julie Vatté, et al. Biguanide-PROTACs: Modulating Mitochondrial Proteins in Pancreatic Cancer Cells. bioRxiv. 2024.05. |