| Bioactivity | PROTAC BTK Degrader-6 (Compound 15) is a PROTAC BTK degrader (DC50: 3.18 nM. PROTAC BTK Degrader-6 has anti-inflammatory activity, inhibits NF-κB activation, and inhibits the expression of pro-inflammatory cytokines (e.g. IL-1β, IL-6)[1]. |
| Target | 3.18 nM (BTK) |
| Name | PROTAC BTK Degrader-6 |
| CAS | 2767204-39-5 |
| Formula | C45H47N11O6 |
| Molar Mass | 837.92 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Huang J, et al. Discovery of Ibrutinib-based BTK PROTACs with in vivo anti-inflammatory efficacy by inhibiting NF-κB activation. Eur J Med Chem. 2023 Jul 18;259:115664. |
PROTAC BTK Degrader-6
CAS: 2767204-39-5 F: C45H47N11O6 W: 837.92
PROTAC BTK Degrader-6 (Compound 15) is a PROTAC BTK degrader (DC50: 3.18 nM. PROTAC BTK Degrader-6 has anti-inflammatory
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