| Bioactivity | PROTAC BRM/BRG1 degrader-3 (compound 304) is a PROTACs-based BRM/BRG1 degrader with a DC50 of less than 1 nM for BRM degradation in SW1573 cells and a DC50 of greater than 1 nM for BRG1 degradation in SW1573 cells. PROTAC BRM/BRG1 degrader-3 has anti-tumor activity and anti-proliferative activity against A549 cells (IC50=0.6 nM). (Srtucture Note: PINK, Target protein ligand (HY-168252); Blue, E3 (HY-168253); Black, linker (HY-69260)). |
| CAS | 2933125-05-2 |
| Formula | C50H63N11O5S |
| Molar Mass | 930.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Peng Gu; et al. Brm selective degradation agent compound and use thereof. WO2023093728. 2022-11-22 |
PROTAC BRM/BRG1 degrader-3
CAS: 2933125-05-2 F: C50H63N11O5S W: 930.17
PROTAC BRM/BRG1 degrader-3 (compound 304) is a PROTACs-based BRM/BRG1 degrader with a DC50 of less than 1 nM for BRM deg
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