| Bioactivity | PROTAC BRM degrader-1 (compound 17) is a PROTAC-based BRM and BRG1 degrader, with DC50 values of 93 pM and 4.9 nM, respectively[1]. |
| Target | PROTAC BRM degrader-1 (compound 17) DC50：93 pM (BRM), 4.9 nM (BRG1) |
| Name | PROTAC BRM degrader-1 |
| CAS | 2378051-80-8 |
| Formula | C57H69N11O8S |
| Molar Mass | 1068.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Berlin M, et al. PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models. J Med Chem. 2024 Jan 5. |
PROTAC BRM degrader-1
CAS: 2378051-80-8 F: C57H69N11O8S W: 1068.29
PROTAC BRM degrader-1 (compound 17) is a PROTAC-based BRM and BRG1 degrader, with DC50 values of 93 pM and 4.9 nM, respe
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