PROTAC AR-V7 degrader-2_product_DataBase

Bioactivity	PROTAC AR-V7 degrader-2 is an AR-based PROTAC. PROTAC AR-V7 degrader-2 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. PROTAC AR-V7 degrader-2 induces apoptosis[1].
Invitro	PROTAC AR-V7 degrader-2 (compound 16; 0-20 μM; 4 d; 22Rvl 细胞) 以剂量依赖性方式抑制细胞生长[1]。PROTAC AR-V7 degrader-2 (10 μM; 4 d; 22Rvl 细胞) 降低 AR-V7 蛋白水平[1]。PROTAC AR-V7 degrader-2 (1 μM; 0-48 h; 22Rvl 细胞) 诱导细胞凋亡并增加膜联蛋白-V 染色[1]。 Cell Viability Assay[1] Cell Line:
In Vivo	PROTAC AR-V7 degrader-2 (compound 16; 2.5 mg/mL; 瘤内注射) 抑制带有 22Rvl-EnzR 肿瘤异种移植物的 nu/nu 小鼠的肿瘤生长[1]。 Animal Model:
Name	PROTAC AR-V7 degrader-2
CAS	2488296-74-6
Formula	C43H53F2N7O7S2
Molar Mass	882.05
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jenny D, et, al. Bi-functional compounds and methods for targeted ubiquitination of androgen receptor. WO2021236695.

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