| Bioactivity | PROTAC ALK degrader-2 (B1-PEG) is an ALK degrader based on PROTACs, with the DC50 of 45 nM in H3122 EML4-ALK DC50 (GSH+). PROTAC ALK degrader-2, through PEGylation, is engineered to self-organize into micelles in water and releases its active form in response to the tumor-specific high GSH environment[1]. |
| Formula | C55H70ClN11O12S3.(C2H4O)n |
| Molar Mass | 3100 (Approximately) |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shirui Wang, et al. Novel Amphiphilic PROTAC with Enhanced Pharmacokinetic Properties for ALK Protein Degradation. J Med Chem. 2024 Jun 27;67(12):9842-9856. |
PROTAC ALK degrader-2
CAS: F: C55H70ClN11O12S3.(C2H4O)n W: 3100 (Approximately)
PROTAC ALK degrader-2 (B1-PEG) is an ALK degrader based on PROTACs, with the DC50 of 45 nM inH3122 EML4-ALK DC50 (GSH+).
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.