| Bioactivity | PROTAC ALK degrader-1 (compound B1) is an ALK degrader based on PROTACs, with the DC50 of 26 nM in H3122 EML4-ALK. PROTAC ALK degrader-1 can be used to synthesis PROTAC ALK degrader-2 (HY-161750) with superior bioavailability[1]. |
| Formula | C47H55ClN10O9S |
| Molar Mass | 971.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shirui Wang, et al. Novel Amphiphilic PROTAC with Enhanced Pharmacokinetic Properties for ALK Protein Degradation. J Med Chem. 2024 Jun 27;67(12):9842-9856. |
PROTAC ALK degrader-1
CAS: F: C47H55ClN10O9S W: 971.52
PROTAC ALK degrader-1 (compound B1) is an ALK degrader based on PROTACs, with the DC50 of 26 nM inH3122 EML4-ALK. PROTAC
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This product is for research use only, not for human use. We do not sell to patients.