| Bioactivity | PROTAC AKR1C3 degrader-1 (compound 5) is a potent AKR1C3 PROTAC degrader. PROTAC AKR1C3 degrader-1 decreases the protein expression of AKR1C3, AKR1C1/2, and ARv7. PROTAC AKR1C3 degrader-1 has the potential for the research of prostate cancer. (Blue:ubiquitin E3 ligase cereblon ligand (HY-A0003), Black: linker (HY-163647); Pink: AKR1C3 inhibitor (HY-163610))[1]. |
| Invitro | PROTAC AKR1C3 degrader-1 (compound 5) (10 nM; 0-72 h) 以时间依赖性方式降低 AKR1C3、AKR1C1/2 和 ARv7 的蛋白水平[1]。PROTAC AKR1C3 degrader-1 (0.001, 0.01, 0.1, 1 µM; 72 h) 以剂量依赖性方式抑制 22Rv1 细胞生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PROTAC AKR1C3 degrader-1 相关抗体: Western Blot Analysis[1] Cell Line: |
| Formula | C45H43N7O10 |
| Molar Mass | 841.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Carmona AV, et al. Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader. Commun Chem. 2024 Apr 29;7(1):95. |
PROTAC AKR1C3 degrader-1
CAS: F: C45H43N7O10 W: 841.86
PROTAC AKR1C3 degrader-1 (compound 5) is a potent AKR1C3 PROTAC degrader. PROTAC AKR1C3 degrader-1 decreases the protein
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