| Bioactivity | PRMT6-IN-3 (compound 25) is a selective PRMT6 inhibitor with an IC50 value of 192 nM. PRMT6-IN-3 can induce apoptosis in cancer cells and has anticancer activity[1]. |
| Invitro | PRMT6-IN-3(compound 25) (80 μM, 3-7 days) has anti-proliferative activity against HCC827 and MDA-MB-435 cells[1]. PRMT6-IN-3(compound 25) (0-40 μM, 72 h) significantly induces apoptosis of cancer cells in a dose-dependent manner. Among them, a concentration of 40 μM could induce apoptosis in 43.44% and 35.08% of HCC827 and MDA-MB-435 cells, respectively[1]. |
| In Vivo | The pharmacokinetic parameters of PRMT6-IN-3(compound 25) in rat Parameters |
| Name | PRMT6-IN-3 |
| CAS | 2890765-10-1 |
| Formula | C19H26N4O2S |
| Molar Mass | 374.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Qiangsheng Zhang, et al. Design, synthesis and evaluation of antitumor activity of selective PRMT6 inhibitors. Eur J Med Chem. 2022 Dec 20;247:115032. |
PRMT6-IN-3
CAS: 2890765-10-1 F: C19H26N4O2S W: 374.50
PRMT6-IN-3 (compound 25) is a selective PRMT6 inhibitor with an IC50 value of 192 nM. PRMT6-IN-3 can induce apoptosis in
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