| Bioactivity | PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative Protein arginine methyltransferase 5 (PRMT5/MAT)[1]. |
| Invitro | PRMT5-IN-34 对各个细胞的抑制增殖活性效果分别为 IC50=0.827 μM (HDLM2); 0.252 μM (L540); 0.077 μM (L1236); 4.638 μM (L428); 0.170 μM (HCT116); 8.538 μM (HCT116)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PRMT5-IN-34 相关抗体: |
| In Vivo | PRMT5-IN-34 (p.o.; 25-100 mg/kg; 每天一次,持续21 天) 抑制 MTAP 沉默的 L540HL 异种移植老鼠模型中的肿瘤生长，SDMA蛋白水平减少[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C23H19F2N5O2 |
| Molar Mass | 435.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. James T et al. Methylthioadenosine (MTA)-cooperative protein arginine methyltransferase 5 (PRMT5) inhibitors for use in the treatment of cancer that is wild type MTAP gene silenced. World Intellectual Property Organization, WO2024038004 A1 2024-02-22 |