| Bioactivity | PRMT5-IN-30 (compound 17) is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.33 μM and a Kd of 0.987 μM. PRMT5-IN-30 exhibits a broad selectivity against a panel of other methyltransferases. PRMT5-IN-30 inhibits PRMT5 mediated SmD3 methylation[1]. | ||||||||||||
| Name | PRMT5-IN-30 | ||||||||||||
| CAS | 330951-01-4 | ||||||||||||
| Formula | C18H17N3O4S | ||||||||||||
| Molar Mass | 371.41 | ||||||||||||
| Appearance | 粉末 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Ruifeng Mao, et al. Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization. J Med Chem. 2017 Jul 27;60(14):6289-6304. |
PRMT5-IN-30
CAS: 330951-01-4 F: C18H17N3O4S W: 371.41
PRMT5-IN-30 (compound 17) is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50
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