| Bioactivity | PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC50=3.2 nM). PRMT4-IN-1 inhibits MCF7 relative viability[1]. |
| Invitro | PRMT4-IN-1（compound 12h）（10 μM、50 μM、100 μM；24 小时、72 小时）对减少代谢活跃细胞的数量没有影响[1]。PRMT4-IN-1（50 μM；2-8 天）在 MCF7 细胞中时间依赖性地降低相对细胞活力[1]。 |
| Name | PRMT4-IN-1 |
| Formula | C30H36N10O7 |
| Molar Mass | 648.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Iannelli G, et al. Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J Med Chem. 2022 Sep 8;65(17):11574-11606. |