| Bioactivity | PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst2) antagonist with a Ki of 12 nM[1]. |
| Invitro | PRL 2915 (0.3-30 nM; 30 min) 剂量依赖性地阻断人尿紧张素 II (human urotensin II) 诱导的大鼠主动脉环的强张性收缩[2]。 |
| Name | PRL 2915 |
| CAS | 209006-18-8 |
| Sequence | {Phe<4-Cl>}-{d-Cys}-{β-Ala<3-Py>}-{d-Trp}-Lys-{Val<3-Me>}-Cys-{2-Nal}-NH2(Disulfide bond) |
| Shortening | {F<4-Cl>}-{d-C}-{β-A<3-Py>}-{d-W}-K-{V<3-Me>}-C-{A<3(2-Naph)>}-NH2 (Disulfide bridge:Cys2-Cys7) |
| Formula | C59H71ClN12O8S2 |
| Molar Mass | 1175.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hocart SJ, et al. Highly potent cyclic disulfide antagonists of somatostatin. J Med Chem. 1999 Jun 3;42(11):1863-71. [2]. Rossowski WJ, et al. Human urotensin II-induced aorta ring contractions are mediated by protein kinase C, tyrosine kinases and Rho-kinase: inhibition by somatostatin receptor antagonists. Eur J Pharmacol. 2002 Mar 8;438(3):159-70. |