PRDX1-IN-2_product_DataBase

Bioactivity	PRDX1-IN-2 (compound 15) is a selective inhibitor of the antioxidant enzyme Peroxiredoxin 1 (PRDX1) (IC50=0.35 μM). PRDX1-IN-2 decreases the mitochondria membrane potential of SW620 cells, probably due to ROS induced by PRDX1 inhibition, leading to cell apoptosis. PRDX1-IN-2 can be used for colorectal cancer research[1].
Invitro	PRDX1-IN-2 (0.5-2 μM， 48 h) 使细胞中 ROS 水平呈剂量依赖性升高[1]。PRDX1-IN-2 可诱导线粒体膜去极化，降低线粒体膜电位，最终导致线粒体功能障碍[1]。PRDX1-IN-2 (0.5， 1， 2 μM； 48 h) 诱导结肠癌细胞凋亡和 G2/M 细胞周期阻滞，可能与其抗增殖活性有关[1]。PRDX1-IN-2 (0.25-2 μM； 48 h)通过调节与线粒体功能障碍相关的促凋亡或抗凋亡标记蛋白诱导 SW620 凋亡，最终导致抗增殖表型[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PRDX1-IN-2 相关抗体: Apoptosis Analysis[1] Cell Line:
In Vivo	PRDX1-IN-2 (20 mg/kg， ip.；每天一次持续 14 天) 具有比天然产物雷公藤红素 (HY-13067) 更高的安全性，可能是由于在 C57BL/314 6J 小鼠中对 PRDX1 的选择抑制活性[1]。PRDX1-IN-2 (2 mg/kg， ig.；每天一次持续 16 天) 通过诱导细胞凋亡成功抑制肿瘤生长，并且耐受性良好在结直肠癌细胞异种移植模型中[1]。药代动力学分析在 C57BL/314 6J 小鼠体内[1]Route
CAS	2566976-43-8
Formula	C35H48N2O5
Molar Mass	576.77
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li Y, et al. Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells[J]. Journal of Medicinal Chemistry, 2024.

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PRDX1-IN-2

CAS: 2566976-43-8 F: C35H48N2O5 W: 576.77