| Bioactivity | PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. In addition, PPOH acts on CYP4A2 and CYP4A3 with the IC50 values of 22 μM and 6.5 μM, respectively[1]. |
| Invitro | PPOH (5 μM) 可以分别抑制 CYP2C9 的活性 63% 和 90%，在没有和存在 30 分钟 NADPH 预孵化的情况下，当 30 分钟预孵化省略NADPH 时，可以抑制 63%[1]。 |
| Name | PPOH |
| CAS | 206052-01-9 |
| Formula | C15H18O3 |
| Molar Mass | 246.30 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Melissa A VanAlstine, et al. Effects of acetylenic epoxygenase inhibitors on recombinant cytochrome p450s. Drug Metab Dispos. 2011 Jul;39(7):1221-6. |