| Bioactivity | PPM-3 is a potent and selective PROTAC ERK5 degrader, with an IC50 of 62.4 nM. PPM-3 did not influence tumor cell growth directly. PPM-3 influences tumor development by affecting the differentiation of macrophages[1]. |
| Invitro | PPM-3 (200 nM, 0-72 h, A375细胞) 介导的 ERK5 降解在 2-4 小时内开始，降解在 12 小时达到峰值，持续至少 72 小时[1]。PPM-3（0-1 μM，12 h）在 H1975、HepG2、MDA-MB-231、PC-3、HCT116 和 A375 癌细胞系中显示 ERK5 降解活性，DC50 值分别为 11.5+2.5、13.7+8.2、22.7+13.3、23.5+10.3、5.6+1.9 和 41.4+22.3 nM[1]。 0 --> PPM-3 相关抗体: |
| Name | PPM-3 |
| Formula | C54H69N11O6S |
| Molar Mass | 1000.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pan P, et al. Design, Synthesis, and Biological Evaluation of Proteolysis-Targeting Chimeras as Highly Selective and Efficient Degraders of Extracellular Signal-Regulated Kinase 5. J Med Chem. 2023 Oct 12;66(19):13568-13586. |