| Bioactivity | PPL agonist-1 is a highly selective Periplakin (PPL) agonist that increases cAMP levels by regulating PPL, thereby enhancing MITF expression and promoting melanin synthesis. Furthermore, PPL agonist-1 facilitates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib (HY-50856), PPL agonist-1 demonstrates superior efficacy. PPL agonist-1 holds potential for research into vitiligo treatment[1]. |
| CAS | 3040997-52-9 |
| Formula | C25H22FN5O4S |
| Molar Mass | 507.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhong H, Li P, Yan Q, Xia Y, Zhang X, Lai Y, Li L, Wang F, Shang J, Zha X. Targeting Periplakin of Novel Benzenesulfonamides as Highly Selective Agonists for the Treatment of Vitiligo. J Med Chem. 2024 Nov 14;67(21):19323-19341. |
PPL agonist-1
CAS: 3040997-52-9 F: C25H22FN5O4S W: 507.54
PPL agonist-1 is a highly selective Periplakin (PPL) agonist that increases cAMP levels by regulating PPL, thereby enhan
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