| Bioactivity | PPARγ/GR modulator 1 is an orally active dual agonist of PPARγ and glucocorticoid receptor (GR), with Kis of 3.3 and 33.6 μM, respectively. PPARγ/GR modulator 1 can be used for the research of metabolic diseases, such as diabetes[1]. |
| Invitro | PPARγ/GR modulator 1 (化合物 11) 刺激 hBM-MSCs 中脂联素和瘦素分泌，IC50 值分别为 2.87 和 2.82 μM[1]。 |
| In Vivo | PPARγ/GR modulator 1 (化合物 11) (25-50 mg/kg; 口服给药 5 天) 降低 STZ 诱导的糖尿病小鼠的血清葡萄糖水平，血清乳酸水平和血清脂联素水平[1]。 Animal Model: |
| Name | PPARγ/GR modulator 1 |
| Formula | C14H10FNO4 |
| Molar Mass | 275.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ahn S, et, al. Discovery of PPARγ and glucocorticoid receptor dual agonists to promote the adiponectin and leptin biosynthesis in human bone marrow mesenchymal stem cells. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114927. |