PPARα/γ agonist 2_product_DataBase

Bioactivity	PPARα/γ agonist 2 is an orally active PPARα full agonist and PPARγ partial agonist. PPARα/γ agonist 2 activates PPARα and PPARγ with EC50 values of 0.95 μM and 0.91 μM respectively. PPARα/γ agonist 2 is also a PTP1B inhibitor. PPARα/γ agonist 2 is an anti-diabetic agent[1].
Invitro	PPARα/γ agonist 2 (化合物 10) 有效抑制 PTP1B，IC50 为 13.2 μM (动力学测定)[1]。PPARα/γ agonist 2 (25 μM，30 分钟) 在 C2C12 细胞中以胰岛素-非依赖性机制增强葡萄糖的摄取，并且比 UK5099 (HY-15475) 更有效[1]。PPARα/γ agonist 2 (25 μM，30 分钟) 降低 C2C12 细胞中的线粒体膜电位[1]。
In Vivo	PPARα/γ agonist 2 (化合物 10) (25 and 50 mg/kg, p.o.) 降低 STZ 诱导的糖尿病小鼠的血糖水平和脂质含量[1]。 Animal Model:
Name	PPARα/γ agonist 2
CAS	2213365-56-9
Formula	C25H20O3
Molar Mass	368.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Laghezza A, et al. A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition. J Med Chem. 2023 Feb 15.

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