| Bioactivity | POP-3MB (compound 1b) is an ICMT inhibitor (IC50: 2.5 μM). POP-3MB changes the subcellular localization of K-Ras and inhibits Ras activation. POP-3MB also inhibits Erk phosphorylation[1]. |
| Target | IC50: 2.5 μM (ICMT) |
| Name | POP-3MB |
| CAS | 1144114-27-1 |
| Formula | C38H39NO4S |
| Molar Mass | 605.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Majmudar JD et al. Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization. Bioorg Med Chem. 2012 Jan 1;20(1):283-95. |