| Bioactivity | POMHEX, a racemic mixture and a cell-permeable pivaloyloxymethyl (POM) prodrug of HEX, is a potent, ENO2-specific inhibitor of enolase. POMHEX exhibits low-nanomolar potency against ENO1-deleted cells in vitro and is capable of eradicating ENO1-deleted xenografted tumours in vivo. POMHEX is a potent glycolysis inhibitor[1]. | ||||||||||||
| Invitro | POMHEx (78 nM, 8h) minimally impacts ENO1-WT glioma cells but profoundly affected ENO1-deleted cells[1].POMHEx (0-720 nM) selectively induces energy stress, inhibits proliferation and triggers apoptosis in ENO1-deleted glioma cells[1]. Cell Proliferation Assay[1] Cell Line: | ||||||||||||
| Name | POMHEX | ||||||||||||
| CAS | 2004714-34-3 | ||||||||||||
| Formula | C17H30NO9P | ||||||||||||
| Molar Mass | 423.40 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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