PNU109291_product_DataBase

Bioactivity	PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation[1].
In Vivo	PNU109291 (0.24、2.4、7.3、24.4、73.3 nmol/kg；皮下注射) 减少猪的三叉神经节刺激引起的硬脑膜血浆外渗[1]。PNU109291 (3 µM) 抑制大鼠弗氏佐剂 (CFA) 诱发的 EPSC（兴奋性突触后电流），但不抑制注射盐水的处理组[2]。 Animal Model:
Name	PNU109291
CAS	187665-60-7
Formula	C24H31N3O3
Molar Mass	409.52
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Cutrer FM, et al. Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically induced dural plasma extravasation and capsaicin-evoked c-fos immunoreactivity within trigeminal nucleus caudalis. Neuropharmacology. 1999 Jul;38(7):1043-53. [2]. Winters BL, et al. Inflammation induces developmentally regulated sumatriptan inhibition of spinal synaptic transmission. Br J Pharmacol. 2020 Aug;177(16):3730-3743.

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