| Bioactivity | PNU-22394 hydrochloride is an agonist for 5-HT, with Ki of 6.1 and 10 nM, for 5-HT2C and 5-HT2A, respectively[1]. |
| In Vivo | PNU-22394 hydrochloride 是 5-HT2C and 5-HT2A 的激动剂，EC50 的值根据测量方法的不同而出现差异 (通过 Fluo-4/Ca2+ 测定法测量为 7.7 和 23 nM；通过 IP-One 测定法测量为 0.12 和 0.21 μM)， Rmax 为 97%-102%[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 15923-42-9 |
| Formula | C13H17ClN2 |
| Molar Mass | 236.74 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ennis MD, et al., 2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT(2C) agonists. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2369-72. [2]. Jensen AA, et al., Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties. J Med Chem. 2013 Feb 14;56(3):1211-27. |
PNU-22394 hydrochloride
CAS: 15923-42-9 F: C13H17ClN2 W: 236.74
PNU-22394 hydrochloride is an agonist for 5-HT, with Ki of 6.1 and 10 nM, for 5-HT2C and 5-HT2A, respectively.
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