PNU-177864_product_DataBase

Bioactivity	PNU-177864 is a potent, selective and orally active dopamine D3 receptor antagonist. PNU-177864 is structurally consistent with a cationic amphiphilic agent (CAD) and induces phospholipidosis in vivo. PNU-177864 antischizophrenic activity[1][2].
In Vivo	PNU-177864 (12.5-200 mg/kg；口服；每天；持续 2-4 周；Sprague-Dawley 大鼠) 治疗在狗或大鼠的异常靶器官 (包括附睾、垂体和毛囊) 中诱导磷脂沉积[ 1]。 Animal Model:
Name	PNU-177864
CAS	250266-51-4
Formula	C18H21F3N2O3S
Molar Mass	402.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Rudmann DG, et al. Epididymal and systemic phospholipidosis in rats and dogs treated with the dopamine D3 selective antagonist PNU-177864. Toxicol Pathol. 2004 May-Jun;32(3):326-32. [2]. Vonderfecht SL, et al. Myopathy related to administration of a cationic amphiphilic drug and the use of multidose drug distribution analysis to predict its occurrence. Toxicol Pathol. 2004 May-Jun;32(3):318-25.

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