| Bioactivity | PNMT-IN-1 (inhibtor 4) is a specific inhibitor of phenylethanolamine N-methyltransferas (PNMT) with a Ki value of 1.2 nM and a IC50 value of 81 nM. PNMT-IN-1 also inhibits the vitality of DNMT1 and DNMT3b, with the IC50 value of 61 μM and 17 μM, respectively, and has an antagonistic effect on epinephrine.PNMT-IN-1 (inhibtor 4 ) is a second generation inhibitor[1]. |
| Target | IC50:81 nM (Phenylethanolamine N-methyltransferase, PNMT )IC50:61 nM (DNMT1)IC50:17 nM (DNMT3b) |
| Invitro | PNMT-IN-1(inhibtor 4)(0.01 μM, 4h) 抑制PNMT的酶活 (IC50 值为 81 nM) 但是不影响蛋白甲基化。 Cell Viability Assay Cell Line: |
| Name | PNMT-IN-1 |
| Formula | C27H36Cl2N8O5 |
| Molar Mass | 623.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Niusha Mahmoodi, et al. Cell-Effective Transition-State Analogue of Phenylethanolamine N‑Methyltransferase. Biochemistry. 2023, 62(15), 2257-2268. |