| Bioactivity | PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis[1]. | ||||||||||||
| Invitro | PND-1186 has an IC50 of ~100 nM in breast carcinoma cells as determined by anti-phospho-specific immunoblotting to FAK Tyr-397[1]. In murine 4T1 breast carcinoma cells, FAK is important in promoting an invasive and metastatic cell phenotype. Increasing concentrations of PND-1186 (0.1 to 1.0 µM) added to 4T1 cells inhibits FAK Tyr-397 phosphorylation (pY397) and results in elevated levels of total FAK protein within 1 h[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | PND-1186 | ||||||||||||
| CAS | 1061353-68-1 | ||||||||||||
| Formula | C25H26F3N5O3 | ||||||||||||
| Molar Mass | 501.50 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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PND-1186
CAS: 1061353-68-1 F: C25H26F3N5O3 W: 501.50
PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 selecti
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