PNB-001_product_DataBase

Bioactivity	PNB-001 is an orally active CCK2 selective ligand and antagonist. PNB-001 has anti-inflammatory and analgesic activities[1].
Target	CCK2
Invitro	PNB-001 (100 nM，30 分钟) 可阻断 CCK4 和 CCK5 诱导的大鼠十二指肠收缩[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PNB-001 相关抗体:
In Vivo	PNB-001 (5 和 20 mg/kg，口服) 具有抗炎活性，并能保护大鼠免受吲哚美辛 (HY-14397) 引起的溃疡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1528760-09-9
Formula	C18H16ClNO2
Molar Mass	313.78
Appearance	固体
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Lattmann E, et al. Cholecystokinin-2/gastrin antagonists: 5-hydroxy-5-aryl-pyrrol-2-ones as anti-inflammatory analgesics for the treatment of inflammatory bowel disease. Medchemcomm. 2017 Feb 17;8(3):680-685.

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