| Bioactivity | PMX 53 monoacetate (3D53 monoacetate) is a potent orally active CD88 (C5aR) antagonist that inhibits C5a-induced neutrophil myeloperoxide release and chemotactic activity. PMX 53 monoacetate has an IC50 value of 20 nM against C5a-induced neutrophil myeloperoxide release. >The value is 22 nM, and the IC50 value of the chemotactic activity is 75 nM. PMX 53 monoacetate is also an agonist of MrgX2[1]. |
| CAS | 852629-88-0 |
| Formula | C49H69N11O9 |
| Molar Mass | 956.14 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells |
PMX 53 monoacetate
CAS: 852629-88-0 F: C49H69N11O9 W: 956.14
PMX 53 monoacetate (3D53 monoacetate) is a potent orally active CD88 (C5aR) antagonist that inhibits C5a-induced neutrop
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