PLK1/BRD4-IN-3_product_DataBase

CAS: 2251709-91-6 F: C31H43N7O3 W: 561.72

PLK1/BRD4-IN-3 (Compound 21) is a selective dual inhibitor for bromodomain 4 (BRD4) and polo-like kinase 1 (PLK1). PLK1/

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity

PLK1/BRD4-IN-3 (Compound 21) is a selective dual inhibitor for bromodomain 4 (BRD4) and polo-like kinase 1 (PLK1). PLK1/BRD4-IN-3 inhibits BRD4-BD1, PLK1 and BRDT-BD1, with IC50s of 0.059, 0.127 and 0.245 μM, respectively[1].

CAS

2251709-91-6

Formula

C31H43N7O3

Molar Mass

561.72

Appearance

固体

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Liu S, et al., Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors. J Med Chem. 2018 Sep 13;61(17):7785-7795.

PeptideDB

PLK1/BRD4-IN-3

CAS: 2251709-91-6 F: C31H43N7O3 W: 561.72