| Bioactivity | PLK1/BRD4-IN-2 (compound 15) is a BI-2536 (HY-50698) analog and dual inhibitor that targets both Polo-like kinase 1 (PLK1) and BRD4bromodomain (BRD4-BD1 IC50=28 nM, PLK1 IC50=40 nM)[1]. | ||||||||||||
| CAS | 2251709-89-2 | ||||||||||||
| Formula | C27H36N6O3 | ||||||||||||
| Molar Mass | 492.61 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Liu S, et al. Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors. J Med Chem. 2018 Sep 13;61(17):7785-7795.https://pubmed.ncbi.nlm.nih.gov/30125504/ |
PLK1/BRD4-IN-2
CAS: 2251709-89-2 F: C27H36N6O3 W: 492.61
PLK1/BRD4-IN-2 (compound 15) is a BI-2536 (HY-50698) analog and dual inhibitor that targets both Polo-like kinase 1 (PLK
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