| Bioactivity | PLK1/BRD4-IN-1 (9b) is an orally active dual PLK1 and BRD4 inhibitor with IC50 values of 22 nM and 109 nM against PLK1 and BRD4, respectively. PLK1/BRD4-IN-1 induces cell cycle arrest and apoptosis, downregulates the transcription of several proliferation-related oncogenes, and exhibits favorable in vivo antitumor activity[1]. |
| Invitro | PLK1/BRD4-IN-1 (9b) (72 h) shows broad-spectrum antiproliferative activities[1].PLK1/BRD4-IN-1 (0-9 µM, 24 h) induces cell cycle arrest[1].PLK1/BRD4-IN-1 (0-9 µM, 48 h) induces cell apoptosis[1].PLK1/BRD4-IN-1 inhibits the proliferative of cancer cells by exerting its inhibitory activity on both PLK1 and BRD4[1]. Cell Viability Assay[1] Cell Line: |
| Name | PLK1/BRD4-IN-1 |
| CAS | 2412707-81-2 |
| Formula | C31H43N9O2 |
| Molar Mass | 573.73 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
PLK1/BRD4-IN-1
CAS: 2412707-81-2 F: C31H43N9O2 W: 573.73
PLK1/BRD4-IN-1 (9b) is an orally active dual PLK1 and BRD4 inhibitor with IC50 values of 22 nM and 109 nM against PLK1 a
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