| Bioactivity | PKMYT1-IN-3 (compound 8ma) is a potent and selective PKMYT1 inhibitor with a IC50 value of 16.5 nM. PKMYT1-IN-3 has antitumor activity[1]. |
| Target | IC50:16.5 nM (PKMYT1). |
| Formula | C24H26FN5O2 |
| Molar Mass | 435.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang C, et al. Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1-Amplified Breast Cancer. J Med Chem. 2024 Sep 12;67(17):15816-15836. |