| Bioactivity | Pkm2-in-4 (compound 5C) is a selective inhibitor of PKM2 (IC50=0.35 μM), which regulates pyruvate-dependent respiration and induces mitochondrial H202 production rate and electron transport system coupling[1]. |
| Target | IC50: 0.35 μM (PKM2) |
| In Vivo | PKM2-IN-4 (compound 5C) |
| Name | PKM2-IN-4 |
| Formula | C15H17BrClNO3Se |
| Molar Mass | 453.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dimitrijevs P, et al. Development of isoselenazolium chlorides as selective pyruvate kinase isoform M2 inhibitors. Eur J Med Chem. 2023 Sep 5;257:115504. |