| Bioactivity | PKL-IN-1 (Compound 12a) is a potent pyruvate kinase L (PKL) inhibitor with IC50 values of 0.07 μM and 0.18 μM for PKL and PKR subtypes, respectively. PKL-IN-1 can inhibit 96.6% PKL activity at 10 μM concentration[1]. |
| Target | IC50: 0.07 μM (PKL) |
| Formula | C12H8O8S |
| Molar Mass | 312.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Matić J, et al. Sulfone-based human liver pyruvate kinase inhibitors - Design, synthesis and in vitro bioactivity. Eur J Med Chem. 2024;269:116306. |