| Bioactivity | PKG1α activator 3 is a PKG1α activator (EC50 basal/partial=13/0.52 μM). PKG1α activator 3 shows anti-proliferative effects to smooth muscle cell, and can be used in cardiovascular disease research[1]. |
| Invitro | PKG1α activator 3 (11.7-33.3 μM; 45 min) shows phosphorylation of VASP[1].PKG1α activator 3 (6.2-22.8 μM; 24 h) inhibits PDGF-induced cell proliferation[1]. Cell Proliferation Assay[1] Cell Line: |
| In Vivo | PKG1α activator 3 shows acceptable in vivo rat pharmacokinetic profiles[1]. |
| Name | PKG1α activator 3 |
| Formula | C27H26Cl2N2O6 |
| Molar Mass | 545.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Victor W Mak, et al. Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α. J Med Chem. 2022 Aug 11;65(15):10318-10340. |