| Bioactivity | PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG). | ||||||
| Invitro | Incorporation of [33P]ATP into the synthetic peptide PKG substrate RKRSRAE is measured. N6-benzyl-ATP inhibits kinase activity of PKG Iα gatekeeper mutants but not WT. The serotonin transporter (SERT) is responsible for reuptake of serotonin (5-hydroxytryptamine) after its exocytotic release from neurons. SERT is regulated by several processes, including a cyclic GMP signaling pathway involving nitric oxide synthase, guanylyl cyclase, and PKG[1]. | ||||||
| Name | PKG Substrate | ||||||
| Sequence | Arg-Lys-Arg-Ser-Arg-Ala-Glu | ||||||
| Shortening | RKRSRAE | ||||||
| Formula | C35H67N17O11 | ||||||
| Molar Mass | 902.01 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |