| Bioactivity | PK-10 is a synergistic antibacterial agent of Fluconazole (HY-B0101) and has strong antifungal activity against a variety of Fluconazole-resistant Candida albicans strains. PK-10 combined with Fluconazole can inhibit hyphae formation and induce the accumulation of reactive oxygen species. It further causes damage to mitochondrial membrane potential, reduces intracellular ATP content, and leads to mitochondrial dysfunction[1]. |
| Name | PK-10 |
| Formula | C35H36F3N5O |
| Molar Mass | 599.69 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sun A, et al. Optimization and antifungal activity of quinoline derivatives linked to chalcone moiety combined with FLC against Candida albicans. Eur J Med Chem. 2023 Nov 15;260:115782.. . |