| Bioactivity | PIM-1/HDAC-IN-1 (compound 4d) is a PIM-1 inhibitor, with an IC50 of 343.87 nM. PIM-1/HDAC-IN-1 has strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC50 values of 63.65 and 62.39 nM, respectively. PIM-1/HDAC-IN-1 exhibits apoptosis inducing potential in MCF-7 cell lines. PIM-1/HDAC-IN-1 shows pre-G1 apoptosis and cell cycle arrest at G2/M phase[1]. |
| Invitro | PIM-1/HDAC-IN-1 (compound 4d) displays strong antiproliferative activity against cancer cell lines, with GI50 (growth inhibitory activity) ≤ 3 μM (GI50 range from 0.325 to 2.9 μM)[1]. |
| Name | PIM-1/HDAC-IN-1 |
| Formula | C22H19N3O3 |
| Molar Mass | 373.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |