| Bioactivity | PIK5-12d is a PROTAC PIKfyve degrader (DC50: 1.48 nM). PIK5-12d induces massive cytoplasmic vacuolization and blocks autophagic flux in multiple prostate cancer cells. PIK5-12d inhibits prostate cancer cell proliferation. PIK5-12d has anti-tumor activity[1]. |
| Name | PIK5-12d |
| Formula | C52H64N10O7S |
| Molar Mass | 973.19 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li C,et al. Discovery of a First-in-Class Degrader for the Lipid Kinase PIKfyve. J Med Chem. 2023 Sep 14;66(17):12432-12445. |