| Bioactivity | PIH is an antiviral peptide that effectively inhibits the HR1/HR2-mediated membrane fusion between MERS-CoV and host cells, with an IC50 of 1.171 μM. By forming a complex with gold nanorods (AuNRs), the antiviral efficacy of PIH can be further enhanced by 10-fold[1]. |
| Sequence | Cys-Gly-Gly-Gly-Gly-Gly-Ser-Leu-Thr-Glu-Ile-Asn-Thr-Glu-Leu-Leu-Asp-Leu-Glu-Tyr-Glu-Met-Lys-Lys-Leu-Glu-Glu-Val-Val-Lys-Lys-Leu-Glu-Glu-Ser-Tyr-Ile-Asp-Leu-Lys-Glu-Leu |
| Shortening | CGGGGGSLTEINTELLDLEYEMKKLEEVVKKLEESYIDLKEL |
| Formula | C207H340N48O72S2 |
| Molar Mass | 4717.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Huang X, et al. Novel Gold Nanorod-Based HR1 Peptide Inhibitor for Middle East Respiratory Syndrome Coronavirus. ACS Appl Mater Interfaces. 2019 Jun 5;11(22):19799-19807. |