| Bioactivity | PID-9 is a P-glycoprotein inhibitor. PID-9 has multidrug resistance (MDR) reversal activity (IC50 = 0.1338 μM) and low toxicity. PID-9 inhibits the transport function of P-gp without downregulating P-gp expression[1]. |
| Invitro | PID-9 (2.5 μM) 会增加耐药 SW620/AD300 细胞中阿霉素 (HY-15142) (10 μM) 的细胞内积累，并增加阿霉素诱导的细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PID-9 相关抗体: |
| Formula | C50H57N5O6 |
| Molar Mass | 824.02 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cao F, et al. Synthesis and evaluation of WK-X-34 derivatives as P-glycoprotein (P-gp/ABCB1) inhibitors for reversing multidrug resistance. RSC Med Chem. 2023 Dec 7;15(2):506-518. |