PI5P4Ks-IN-2

CAS: 2766854-03-7 F: C22H23N5 W: 357.45

PI5P4Ks-IN-2 is a inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ). PI5P4Ks-IN-2 targets to PI5P4K i

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Bioactivity	PI5P4Ks-IN-2 is a inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ). PI5P4Ks-IN-2 targets to PI5P4K isoforms with pIC50 values of <4.3 (PI5P4Kα), <4.6 (PI5P4Kβ), 6.2 (PI5P4Kγ), 0.32 (PI5P4Kγ+), respectively[1].
Target	PI5P4K
Invitro	PI5P4Ks-IN-2 (compound 40) (10 μM) 对一组 140 种蛋白激酶和 15 种脂质激酶表现出选择性，并结合 PI5P4Kγ-WT (Ki=68 nM) 或 PI5P4Kβ ( Ki >30,000 nM)[1]。
Name	PI5P4Ks-IN-2
CAS	2766854-03-7
Formula	C22H23N5
Molar Mass	357.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Boffey HK, et al. Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode. J Med Chem. 2022 Feb 24;65(4):3359-3370.

PLX5622 in AIN-76A Diet (1200 ppm)