| Bioactivity | PI3Kδ-IN-22 (Compound 26) is a selective inhibitor for PI3Kδ with pKi of 9.3. PI3Kδ-IN-22 inhibits PI3Kδ-AKT signaling pathway in THP-1 cells, with pIC50 of 9.4. PI3Kδ-IN-22 exhibits good pharmacokinetic characters in rats[1]. |
| Formula | C27H35FN8O4S |
| Molar Mass | 586.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bruno P, et al., Discovery and Optimization of Pyridazinones as PI3K Selective Inhibitors for Administration by Inhalation. J Med Chem. 2024 Jun 22. |