| Bioactivity | PI3Kδ-IN-14 (Compound (S)-29) is a selective PI3Kδ inhibitor (IC50: 0.8 nM, Kd: 84.8 nM). PI3Kδ-IN-14 binds to the ATP-binding site of the kinase domain of PI3Kδ. PI3Kδ-IN-14 has anti-inflammatory activity by inhibiting the PI3K/AKT pathway. PI3Kδ-IN-14 ameliorates acute lung injury (ALI)[1]. |
| Target | 0.8 nM (PI3Kδ) |
| Name | PI3Kδ-IN-14 |
| Formula | C26H20ClFN8O |
| Molar Mass | 514.94 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tang Y, et al. Discovery of Highly Selective and Orally Bioavailable PI3K未 Inhibitors with Anti-Inflammatory Activity for Treatment of Acute Lung Injury. J Med Chem. 2023 Aug 22. |