| Bioactivity | PI3Kγ inhibitor 7 (compound 2) is a potent and orally active PI3Kγ inhibitor with IC50 values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. PI3Kγ inhibitor 7 shows antitumor activity[1]. |
| In Vivo | PI3Kγ inhibitor 7 (compound 2) (5 mg/kg；口服) 在 ICR 小鼠中表现出良好的药代动力学吸收，t1/2 为 3.4 小时，F 为 60%[1]。PI3Kγ inhibitor 7 (60 mg/kg；口服；每日一次，持续 21 天） 在小鼠中显示出抗肿瘤活性[1]。 Animal Model: |
| Name | PI3Kγ inhibitor 7 |
| CAS | 2575863-25-9 |
| Formula | C31H25N9O2 |
| Molar Mass | 555.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. HeJun Lv, et al. Alkyne derivative, preparation method for same, and uses thereof. WO2021004421A1. |
PI3Kγ inhibitor 7
CAS: 2575863-25-9 F: C31H25N9O2 W: 555.59
PI3Kγ inhibitor 7 (compound 2) is a potent and orally active PI3Kγ inhibitor with IC50 values of 4768, 878.1, 3.42, 35
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