| Bioactivity | PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor. PI3Kα-IN-6 exhibits anticancer potential and no toxicity in normal cells. PI3Kα-IN-6 increases generation of ROS, reduces mitochondrial membrane potential (MMP) and induces apoptosis[1]. |
| Invitro | PI3Kα-IN-6 (Compound 5b) shows cell growth inhibition with IC50 values of 3.5, 8.7, 8.9, 26.5, 89.9, 61.1 and 112.02 against HCT-116, A-549, MiaPaca-2, MCF-7, MDA-MB-231, PC-3 and HEK-293 cells, respectively[1]. |
| Name | PI3Kα-IN-6 |
| CAS | 2272894-14-9 |
| Formula | C16H15IN2OS |
| Molar Mass | 410.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
PI3Kα-IN-6
CAS: 2272894-14-9 F: C16H15IN2OS W: 410.27
PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor. PI3Kα-IN-6 exhibits anticancer potential and no toxicity in normal cel
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